Total synthesis of (+)-aglacin B employs chiral auxiliary and nickel-promoted reactions, indicating efficient natural product construction.
The total synthesis of bioactive (+)-aglacin B was achieved. The key steps include an asymmetric conjugate addition reaction induced by a chiral auxiliary and a nickel-promoted reductive tandem cyclization of the elaborated β-bromo acetal, which led to the efficient construction of the aryltetralin[2,3- c ]furan skeleton embedded in this natural product.
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Yao et al. (2025) studied this question.
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