What question did this study set out to answer?

Evaluate colonoscopy follow-up rates and diagnostic outcomes after positive Cologuard test results.

November 18, 2025Journal of Gastrointestinal CancerOpen Access

From Detection to Delay: Real-World Gaps in Post-Cologuard® Colonoscopy Adherence

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Authors

MKMuhammad Ali Ibrahim Kazi IQImran Qureshi ASAkshay Sharma

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Overview

Retrospective cohort study finds 44% adherence to follow-up colonoscopy after positive Cologuard results, indicating need for improved patient education.

Key Points

Evaluate colonoscopy follow-up rates and diagnostic outcomes after positive Cologuard test results.
Retrospective cohort study using TriNetX database
Analyzed patients aged ≥ 18 who tested positive on Cologuard
Primary outcome: endoscopic procedure adherence within 12 months
Secondary outcome: diagnoses from follow-up colonoscopy
3,916 patients tested with Cologuard; 61.3% female, 35% male
44% of 385 positive Cologuard patients underwent colonoscopy within 12 months
5.8% diagnosed with malignant neoplasms
32.7% diagnosed with benign neoplasms (polyps)
High false positive rate with only 38.5% showing significant lesions

Cite This Study

Kazi et al. (2025) studied this question.

synapsesocial.com/papers/6924fef9c0ce034ddc351e30 https://doi.org/10.1007/s12029-025-01350-5

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November 18, 2025Journal of Gastrointestinal CancerOpen Access

From Detection to Delay: Real-World Gaps in Post-Cologuard® Colonoscopy Adherence

View Full Paper

Ask AI

Bookmark

Authors

MKMuhammad Ali Ibrahim Kazi IQImran Qureshi ASAkshay Sharma

Discussion

Member takes

Overview

Retrospective cohort study finds 44% adherence to follow-up colonoscopy after positive Cologuard results, indicating need for improved patient education.

Key Points

Evaluate colonoscopy follow-up rates and diagnostic outcomes after positive Cologuard test results.
Retrospective cohort study using TriNetX database
Analyzed patients aged ≥ 18 who tested positive on Cologuard
Primary outcome: endoscopic procedure adherence within 12 months
Secondary outcome: diagnoses from follow-up colonoscopy
3,916 patients tested with Cologuard; 61.3% female, 35% male
44% of 385 positive Cologuard patients underwent colonoscopy within 12 months
5.8% diagnosed with malignant neoplasms
32.7% diagnosed with benign neoplasms (polyps)
High false positive rate with only 38.5% showing significant lesions

Cite This Study

Kazi et al. (2025) studied this question.

synapsesocial.com/papers/6924fef9c0ce034ddc351e30 https://doi.org/10.1007/s12029-025-01350-5

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