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This research explores the role of M-CSF and mTOR in maintaining splenic macrophages through antioxidative programs.

November 25, 2025The Journal of ImmunologyOpen Access

Splenic macrophages imprinted with an antioxidative program for tissue residency and homeostasis 9109

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Findings reveal homeostasis and oxidative stress responses in splenic macrophages, indicating a distinct antioxidative pathway.

This research explores the role of M-CSF and mTOR in maintaining splenic macrophages through antioxidative programs.
Examined the impact of M-CSF on tissue-resident macrophages.
Administered antioxidant vitamin E Trolox and evaluated effects on splenic macrophages.
Investigated the role of mTOR and its downstream effectors in macrophage maintenance.
Depriving M-CSF reduced tissue macrophages universally but restored splenic macrophages with Trolox.
mTOR regulated an antioxidative program essential for splenic macrophage functionality.
Splenic macrophages demonstrated increased reliance on Gpx4 during oxidative stress challenges.

XIAO et al. (2025) studied this question.

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