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September 12, 2025HaematologicaOpen Access

Splenic erythrophagocytosis is regulated by ALX/FPR2 signaling

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This study demonstrates the role of ALX/FPR2 in erythrophagocytosis in macrophages, indicating altered RBC homeostasis.

ALX/FPR2 signaling is essential for maintaining red blood cell homeostasis in the spleen, impacting macrophage function.
Mice with Fpr2 deletion show impaired erythrophagocytosis and elevate aged red blood cell pools due to dysfunctional macrophage activity.
Activation of lipoxin A4 is critical for erythrophagocytosis, suggesting its therapeutic potential in maintaining RBC turnover.
Disrupted macrophage phenotypes and heme metabolism were observed in Fpr2-deficient mice, pointing to key roles in RBC recycling.

Asplund et al. (2025) studied this question.

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