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This research aims to understand the distinct roles of CD4+ and CD8+ regulatory T cells in autoimmunity.

November 25, 2025The Journal of ImmunologyOpen Access

Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses 2723

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Analysis reveals distinct roles of CD4+ and CD8+ regulatory T cells in controlling autoimmunity, suggesting important immune response implications.

This research aims to understand the distinct roles of CD4+ and CD8+ regulatory T cells in autoimmunity.
Analyzed CD4+ and CD8+ regulatory T cells in human tonsil-derived immune organoids.
Utilized CRISPR-Cas9 gene editing to reduce FOXP3 and GZMB expression by 90-95%.
Monitored changes in antibody production and T cell populations post-gene knockout.
Knockout of FOXP3 increased autoantibody production against various autoantigens.
Increased affinity of influenza-specific antibodies observed after FOXP3 knockout.
GZMB knockout resulted in increased follicular helper T cells and autoreactive CD8+ and CD4+ T cells.

Chen et al. (2025) studied this question.

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Analysis reveals distinct roles of CD4+ and CD8+ regulatory T cells in controlling autoimmunity, suggesting important immune response implications.