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November 1, 2025The Journal of ImmunologyOpen Access

Dissecting the heterogeneity and specificity of regulatory CD8 T cells 3127

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Authors

KRKa Hyun RheeKBKatharine E. BlockRMRyan J Martinez

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Overview

Single-cell RNA sequencing reveals heterogeneity of CD8 Tregs in immune response and autoimmunity.

Key Points

  • This research aims to elucidate the heterogeneity and specificity of regulatory CD8 T cells and their functional mechanisms.
  • Conducted single-cell RNA sequencing on Ly49+ or Helios+ regulatory CD8 T cells.
  • Performed TCR repertoire analysis on cells from mice with a fixed TCRβ chain.
  • Compared CD8 Tregs with conventional memory phenotype populations.
  • Identified multiple subsets of regulatory CD8 T cells with potential overlapping TCR repertoires.
  • Found that regulatory CD8 T cells may recognize self-antigens expressed in tumors.
  • Revealed that Helios+ populations are prominent among prostate tumor-infiltrating lymphocytes.

Cite This Study

Rhee et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3598aehttps://doi.org/10.1093/jimmun/vkaf283.963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD8+hla-DR+CD27+ t cells define a population of naturally occurring regulatory precursors in humans2025 · 1 citations
  2. 2Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses 27232025
  3. 3Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer2026
  4. 4ImmgenT Regulatory T Cell Atlas 22528252026
  5. 5Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism2024