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December 8, 2025Blood

CD8+hla-DR+CD27+ t cells define a population of naturally occurring regulatory precursors in humans

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Authors

HGHuidong GuoBWBixia Wang

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Overview

Observations reveal CD8+ HLA-DR+ CD27+ T cells regulate immune responses in humans, suggesting their role in graft-versus-host disease.

Key Points

  • This research investigates the characterization and function of CD8+ regulatory precursors in immune regulation.
  • Analyzed PBMCs from healthy donors and allo-HSCT recipients
  • Employed single-cell RNA sequencing and flow cytometry
  • Conducted in vitro co-culture and mixed lymphocyte reaction models
  • Investigated transcriptomic and epigenetic profiles with RNA-seq and ATAC-seq
  • CD8+ HLA-DR+ CD27+ cells display characteristics of regulatory T cells
  • These cells suppressed PBMC proliferation and cytokine production
  • Co-infusion with CD8+ T regulatory precursors reduced graft-versus-host disease damage
  • Increased frequencies of FOXP3+ cells were observed in CD8+ T precursor groups

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dab7https://doi.org/10.1182/blood-2025-4080
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