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June 14, 2026Frontiers in ImmunologyOpen Access

CD25+CD27+CD70− alloantigen-specific Tregs: promising stable immunotherapy for transplantation

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Authors

ACArimelek Cortés-HernándezSASaúl Arteaga-CruzIIIyari I. Martínez Iturbe

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Overview

Randomized trial demonstrates that CD25+CD27+CD70− Tregs enhance immunoregulation in transplantation, implying safer outcomes.

Key Points

  • The aim is to develop a stable population of alloantigen-specific regulatory T cells for transplantation immunotherapy.
  • CD25+CD27+CD70− Tregs were isolated and expanded using allogeneic dendritic cells, IL-15, IL-2, and retinoic acid.
  • Expanded via anti-CD3/CD28 stimulation with IL-15, IL-2, rapamycin, and TGF-β over three weeks.
  • Total expansion of 434-fold with >95% purity and functional analysis for immunoregulatory properties.
  • CD27+ AS-Tregs showed >60% FOXP3-TSDR demethylation, indicating stable Treg lineage commitment.
  • CD27+ AS-Tregs suppressed antigen-specific T cell proliferation despite inflammatory cytokine exposure.
  • Transcriptional profiling indicated enriched immunoregulatory signatures with minimal gene expression changes under inflammatory conditions.

Cite This Study

Cortés-Hernández et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4429b1cc60ccdea8a0cbhttps://doi.org/10.3389/fimmu.2026.1789008
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  4. 4Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival2026
  5. 5Current Status of Treg Therapy in Transplantation and Autoimmune Disease2026 · 1 citations