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November 8, 2022Frontiers in ImmunologyOpen Access

CD4+CD25+ T regulatory cells in renal transplantation

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Authors

JCJason Pui Yin CheungBZBeata ZahorowskaMSMichael Suranyi

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Overview

Review shows T regulatory cells impact graft survival and rejection in renal transplantation, suggesting targeted immunomodulation may help.

Key Points

  • The central aim is to explore the role of CD4+CD25+ Foxp3+ T regulatory cells in renal transplantation and their impact on immune response and graft survival.
  • Review of methods to monitor peripheral T regulatory cells
  • Evaluation of the impact of immunosuppressive regimens on T regulatory cells
  • Examination of correlations between T regulatory cells and clinical outcomes like graft survival and rejection.
  • Activated T regulatory cells are crucial for promoting operational tolerance and may improve graft survival.
  • Characterization of T regulatory cells can identify those that are more effective at preventing rejection.
  • Monitoring activated T regulatory cells provides insights into the immune tolerance process, rather than relying on total T regulatory cell counts.

Cite This Study

Cheung et al. (2022) studied this question.

synapsesocial.com/papers/6a21ce13cfdd5cd1d31596ebhttps://doi.org/10.3389/fimmu.2022.1017683
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation2009 · 259 citations
  2. 2TR3-56 and Treg Regulatory T Cell Subsets as Potential Indicators of Graft Tolerance Control in Kidney Transplant Recipients2024 · 4 citations
  3. 3#1167 Examination of subsets of CD4+ lymphocyte subpopulations in long-surviving renal transplant patients2024
  4. 4CD25+CD27+CD70− alloantigen-specific Tregs: promising stable immunotherapy for transplantation2026
  5. 5The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance2024 · 4 citations