What question did this study set out to answer?

To investigate the role of monocyte trogocytosis of tumor cells in modulating immune response and its implications for therapy.

November 25, 2025The Journal of ImmunologyOpen Access

Uncovering the key mediators of monocyte trogocytosis of cancer cells and implications on monocyte function, antibody efficacy and antigen presentation 4363

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To investigate the role of monocyte trogocytosis of tumor cells in modulating immune response and its implications for therapy.
Utilized functional analyses to explore signaling pathways involved in monocyte trogocytosis.
Conducted genome-wide and targeted CRISPR/Cas9 screens to identify regulators of trogocytosis.
Performed transcriptomic analysis to assess gene expression changes in trogocytic monocytes.
Monocyte trogocytosis was identified as a key mechanism in tumor cell communication.
Rho GTPase signaling was found to significantly regulate the trogocytosis process.
Trogocytic monocytes showed increased expression of MHC II and complement-related genes, indicating enhanced antigen presentation and inflammatory response.

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Implication

Functional analysis reveals that monocyte trogocytosis enhances antigen presentation in cancer cells, suggesting new targets for improving immunotherapy.

Cite This Study

Contreras et al. (2025) studied this question.

synapsesocial.com/papers/692502be87af00ed34ac219f https://doi.org/10.1093/jimmun/vkaf283.2057

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Implication

Functional analysis reveals that monocyte trogocytosis enhances antigen presentation in cancer cells, suggesting new targets for improving immunotherapy.

Uncovering the key mediators of monocyte trogocytosis of cancer cells and implications on monocyte function, antibody efficacy and antigen presentation 4363

Key Points

Discussion

Implication

Cite This Study

Uncovering the key mediators of monocyte trogocytosis of cancer cells and implications on monocyte function, antibody efficacy and antigen presentation 4363

Key Points

Discussion

Implication

Cite This Study

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