What question did this study set out to answer?

The study aims to understand how tumor-associated macrophages and neutrophils regulate the response to tumor-targeting antibodies.

November 1, 2025The Journal of ImmunologyOpen Access

Dual role of Fc Receptor-triggered trogocytosis mediated by human tumor-infiltrating macrophages and neutrophils in the regulation of anti-tumor antibody efficacy 3084

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The study aims to understand how tumor-associated macrophages and neutrophils regulate the response to tumor-targeting antibodies.
Investigated interactions of myeloid effectors with tAb-opsonized cancer cells.
Analyzed conditions for effective antibody-dependent trogocytosis (ADT).
Examined effects of various tAb types on tumor cell growth and immune responses.
Tumor-associated macrophages mediate sublethal ADT, facilitating tumor escape.
High ratios of myeloid effectors to tumor cells enhance ADT only if tumor cells express high tAg levels.
IgA tAbs demonstrate tumoricidal activity while IgG1 tAbs stimulate tumor cell growth.

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Implication

Research reveals Fc receptor-triggered trogocytosis impacts tumor-targeting antibody efficacy in the tumor microenvironment, suggesting new therapeutic approaches.

Cite This Study

Eruslanov et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc359947 https://doi.org/10.1093/jimmun/vkaf283.923

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Implication

Research reveals Fc receptor-triggered trogocytosis impacts tumor-targeting antibody efficacy in the tumor microenvironment, suggesting new therapeutic approaches.

Dual role of Fc Receptor-triggered trogocytosis mediated by human tumor-infiltrating macrophages and neutrophils in the regulation of anti-tumor antibody efficacy 3084

Key Points

Discussion

Implication

Cite This Study

Dual role of Fc Receptor-triggered trogocytosis mediated by human tumor-infiltrating macrophages and neutrophils in the regulation of anti-tumor antibody efficacy 3084

Key Points

Discussion

Implication

Cite This Study

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