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This research aims to clarify the role of memory-like NK cells in immunity against malaria.

November 25, 2025The Journal of ImmunologyOpen Access

Memory-like NK cells protective roles or lack thereof in uncomplicated and severe malaria 2107

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Research demonstrates memory-like NK cells enhance immunity and reduce parasitemia in malaria, indicating their protective function.

This research aims to clarify the role of memory-like NK cells in immunity against malaria.
Assessed antibody dependent cellular cytotoxicity (ADCC) in a large malaria cohort.
Evaluated the role of memory-like NK cells and their factors affecting ADCC.
Investigated the impact of CRISPR-mediated ablation of Fc γ chain and Siglec 7 on NK cell function.
Memory-like NK cells lacking Fc γ chain correlated with clinical immunity and reduced parasitemia.
Increased ADCC and IFNγ production were observed in memory-like NK cells.
Ablation of Siglec 7 led to increased ADCC and IFNγ production.

Dick et al. (2025) studied this question.

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