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November 25, 2025The Journal of ImmunologyOpen Access

Hyaluronic acid impacts the inflammatory potential and pathogenicity of autoreactive Th17 cells 3039

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Authors

LALaxmi Prasad AdhikariKWKaitlyn WoodmanJRJoseph M Reynolds

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Implication

Research demonstrates hyaluronic acid influences IL-17 levels in Th17 cells, suggesting its role in autoimmune disease modulation.

Key Points

  • This research aims to investigate the influence of hyaluronic acid on the pathogenic potential of autoreactive Th17 cells in autoimmune diseases.
  • Examined the role of hyaluronic acid in Th17 cell differentiation and proliferation.
  • Assessed the effects of hyaluronic acid synthase overexpression on Th17 cells in vitro.
  • Executed adoptive transfer experiments in mice to evaluate Th17 cell pathogenicity.
  • Hyaluronic acid increases IL-17 production in Th17 cells but decreases their proliferation.
  • Overexpression of hyaluronic acid synthase improved EAE outcomes in mice.
  • Hyaluronidase overexpression in Th17 cells led to exacerbated EAE despite lower cytokine levels.

Cite This Study

Adhikari et al. (2025) studied this question.

synapsesocial.com/papers/692502be87af00ed34ac22f1https://doi.org/10.1093/jimmun/vkaf283.879
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Also Consider

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  1. 1Hyaluronan Accumulates in Inflamed Lymph Nodes and Promotes B‐Cell Activation2025 · 1 citations
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  5. 5Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis2024