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This research aims to understand how RORγt influences regulatory T-cell function in cancer progression.

November 25, 2025The Journal of ImmunologyOpen Access

A small but mighty ROR(γt): RORγt supports peripherally induced regulatory T-cell function and tumor growth 4146

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Findings reveal that RORγt promotes tumor growth in regulatory T-cells via microbiota, indicating its role in improving immunotherapy outcomes.

This research aims to understand how RORγt influences regulatory T-cell function in cancer progression.
Utilized Foxp3CreERT2Rorcfl/fl mice to study RORγt expression
Analyzed the impact of RORγt on Foxp3 expression and suppressive function in pTregs
Examined tumor infiltrating lymphocytes including Th17 and CD8+ T cells
Investigated the dependence of pTreg function on gut microbiome
RORγt expression was found to stabilize Foxp3 expression in pTregs
Tumor growth was promoted through increased suppressive function of pTregs
Increased presence of tumor infiltrating lymphocytes was observed in Foxp3CreERT2Rorcfl/fl mice
Functional changes in pTregs were linked to alterations in the gut microbiome

Ertwine et al. (2025) studied this question.

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Findings reveal that RORγt promotes tumor growth in regulatory T-cells via microbiota, indicating its role in improving immunotherapy outcomes.