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July 7, 2026Cell Death and DiseaseOpen Access

Disrupting Treg lineage stability elicits RORgT-mediated plasticity and enhances anti-tumor immunity

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Authors

CSCourtney A. SwainDHDominique C. HinshawIMIan D. Miranda

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Overview

Randomized trial reveals enhanced anti-tumor immunity in a modified mouse model by targeting Gli2 in Tregs, suggesting new therapeutic avenues.

Key Points

  • To explore the role of Gli2 signaling in Tregs and its impact on anti-tumor immunity.
  • Developed a genetically modified mouse model to conditionally ablate Gli2 gene in Tregs.
  • Analyzed tumor burden and Treg function post-ablation.
  • Conducted spatial mapping for immune cell infiltration in tumors.
  • Ablation of Gli2 in Tregs significantly reduced tumor burden and impaired Treg function.
  • Enhanced infiltration of cytotoxic CD8+ T cells was observed in tumors.
  • An increased tumor immune signature score indicated a more pro-inflammatory tumor microenvironment.

Cite This Study

Swain et al. (2026) studied this question.

synapsesocial.com/papers/6a4c9711331bc25c9e5f436ehttps://doi.org/10.1038/s41419-026-09025-0
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Also Consider

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  1. 1Abstract 5003: Treg-specific inhibition of hedgehog signaling alters their function and impedes the growth of murine triple-negative breast cancer2026
  2. 2A small but mighty ROR(γt): RORγt supports peripherally induced regulatory T-cell function and tumor growth 41462025
  3. 3Reprogramming regulatory T cell plasticity for cancer immunotherapy2026
  4. 4Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments2026
  5. 5Regulatory T cells sabotage antitumor γδ T cells by creating IL-2-deficient environments2025 · 2 citations