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May 11, 2026Biochimica et Biophysica Acta (BBA) - Reviews on CancerOpen Access

Reprogramming regulatory T cell plasticity for cancer immunotherapy

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Authors

MIMark E. IssaASAlejandro Schcolnik-CabreraRMRosanna Monetta

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Overview

Review outlines strategies to enhance anti-tumor immunity by reprogramming regulatory T cells' plasticity.

Key Points

  • This review aims to explore harnessing the plasticity of regulatory T cells to improve cancer immunotherapy outcomes.
  • Examined literature on Treg plasticity and its implications for tumor immunity.
  • Reviewed the roles of transcription factors like T-bet and RORγt in Treg differentiation.
  • Discussed potential therapeutic strategies utilizing Treg plasticity.
  • Highlight the ability of Tregs to adopt inflammatory phenotypes in tumor microenvironments.
  • Emphasize the crucial role of environmental cues in shaping Treg functions.
  • Propose that leveraging Treg plasticity may lead to better therapeutic outcomes than current depletion strategies.

Cite This Study

Issa et al. (2026) studied this question.

synapsesocial.com/papers/6a0171983a9f334c28271ba7https://doi.org/10.1016/j.bbcan.2026.189605
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