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November 17, 2025CellsOpen Access

Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration

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Authors

FGFei GaoYZYuqiang ZhengTWTianyi Wang

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Implication

Conditional knockdown of BAP31 reveals its role in retinal degeneration, suggesting ER stress mediates photoreceptor dysfunction.

Key Points

  • This study investigates the role of BAP31 in retinal degeneration and its relationship with ER stress.
  • Conditional knockdown of BAP31 was performed in a mouse model (Rho-iCre-BAP31fl/fl(−/−)).
  • The study assessed retinal degeneration through ERG, OCT, histopathology, and RNA sequencing.
  • The expression of genes involved in phototransduction and the unfolded protein response were analyzed.
  • Knockdown mice exhibited decreased ERG responses and progressive photoreceptor degeneration.
  • OCT revealed thinning of the outer nuclear layer after 9 months, consistent with histopathological findings.
  • RNA sequencing showed enrichment of the phototransduction pathway with downregulated rhodopsin and other key genes.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/692509e3c0ce034ddc3525a4https://doi.org/10.3390/cells14221802
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biallelic BAIAP3 Variants Are Associated with Isolated Retinitis Pigmentosa2025
  2. 2BAP31 Modulates Mitochondrial Homeostasis Through PINK1/Parkin Pathway in MPTP Parkinsonism Mouse Models2026 · 1 citations
  3. 3BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling2024 · 2 citations
  4. 4Retinal Organoid Single-Cell Transcriptomics Reveals Effects of PRPF31 Mutation on Early Müller Glial Activation and Progressive Photoreceptor Degeneration2025
  5. 5Activation of ER stress mediated by HspB4/Cryaa reduction contributes to photoreceptor apoptosis in rd9 mouse model of X-linked Retinitis Pigmentosa2026