Meta-analysis reveals molecular profiling improves risk stratification and prognostic models in pediatric acute myeloid leukemia.
WT1 overexpression and KIT mutations (in selected cytogenetic contexts) are validated as adverse prognostic indicators in pediatric AML. Conversely, FLT3-ITD and CEBPA mutations require nuanced interpretation due to variable effects and methodological heterogeneity. These findings support the integration of molecular profiling into pediatric AML risk stratification and underscore the need for harmonized, prospective studies to refine prognostic models in this population.
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Huang et al. (2025) studied this question.
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