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November 17, 2025International Journal of Molecular SciencesOpen Access

The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions

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Authors

PGPaola GiussaniLMLaura MauriSSSandro Sonnino

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Implication

This review highlights interactions among ceramide, sphingosine-1-phosphate, and GM1 in neurological disorders, suggesting neuroprotective mechanisms.

Key Points

  • To summarize the role of sphingolipids in maintaining nervous system health and function.
  • Review of existing literature on sphingolipid metabolism.
  • Analysis of the roles of ceramide and sphingosine-1-phosphate in neurological functions.
  • Evaluation of GM1's neuroprotective effects and its importance in neuronal signaling.
  • Sphingolipids are crucial for membrane organization and neuron signaling.
  • Altered levels of ceramide and sphingosine-1-phosphate are linked to various neurological disorders.
  • GM1 is vital for neuronal membrane receptor function, impacting neurodegenerative disease progression.

Cite This Study

Giussani et al. (2025) studied this question.

synapsesocial.com/papers/692509eec0ce034ddc3529b9https://doi.org/10.3390/ijms262211118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction2009 · 282 citations
  2. 2The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system2025 · 14 citations
  3. 3Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System2026 · 1 citations
  4. 4The riddle of sphingolipid structure-function relationship in the nervous system2026
  5. 5Sphingolipids in human disease: organ-specific pathologies, chain-length-dependent effects, and translational implications2026