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March 19, 2026ReceptorsOpen Access

Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System

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Authors

EGElizabeth GulliksenVirginia Commonwealth UniversitySDSriya DarsiUniversity of North Carolina at Chapel HillLHLadan HaidarbaigiVirginia Commonwealth University

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Implication

Research highlights mechanisms of sphingosine-1-phosphate signaling in the CNS, suggesting new therapeutic avenues for neurodegenerative disorders.

Key Points

  • The research aims to explore the role and therapeutic potential of sphingosine-1-phosphate receptors in the central nervous system.
  • Review of existing literature on sphingolipids and their signaling pathways
  • Analysis of therapeutic agents targeting sphingosine-1-phosphate receptors
  • Examination of the clinical implications for neurodegenerative diseases
  • Sphingosine-1-phosphate receptors are critical for signaling in the CNS.
  • Targeting these receptors has potential benefits in treating neurodegenerative diseases.
  • Recent small molecules focusing on these receptors have entered clinical trials.

Cite This Study

Gulliksen et al. (2026) studied this question.

synapsesocial.com/papers/69bb92be496e729e62980444https://doi.org/10.3390/receptors5010009
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