This study demonstrates hyperactivation of Wnt signaling in colorectal cancer, highlighting P2-HNF4α as a therapeutic target and feedback loop driver.
This study identifies P2-HNF4α as a novel downstream effector of the Wnt/β-catenin pathway and a critical driver of CRC progression. The Wnt/β-catenin/HNF4α feedback loop identified here provides mechanistic insights into colorectal carcinogenesis and highlights P2-HNF4α as a potential therapeutic target. These findings may inform strategies to disrupt Wnt signaling hyperactivation in CRC.
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Bai et al. (2025) studied this question.
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