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November 17, 2025Environmental Science & Technology

Shedding Light on PFAS Dark Matter Using a Novel GC-HRMS Approach

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Authors

JKJeremy P KoelmelELElizabeth Z. LinPCParker Chang

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Overview

Nontargeted approach reveals previously undetected PFAS in human blood and environmental samples, indicating significant health and environmental risks.

Key Points

  • Nontargeted workflow identified new PFAS compounds in human blood and environmental samples.
  • A novel compound, 2-(perfluorohexyl)ethanethiol, was discovered in aqueous film forming foam.
  • Comparison of gas chromatography and liquid chromatography highlighted gaps in PFAS detection.
  • Expanded monitoring capabilities can address significant health and environmental risks posed by unknown PFAS.

Cite This Study

Koelmel et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc352e6fhttps://doi.org/10.1021/acs.est.5c11712
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Consolidating LC×LC-HRMS/MS Technique for the Non-targeted Analysis of Poly- And Perfluorinated Substances: a Trial on Aqueous-Film Forming Foams.2024
  2. 2Suspect Screening for PFAS in Groundwater with an Accessible LC–MS Workflow2026
  3. 3Consolidating two-dimensional liquid chromatography–high-resolution tandem mass spectrometry (LC×LC-HRMS/MS) technique for the non-targeted analysis of poly- and perfluorinated substances: A trial on aqueous film-forming foams2024 · 5 citations
  4. 4Understanding and Reporting PFAS Exposure: Wide-Scope Retrospective Suspect Screening of High-Resolution Mass Spectrometry Data from Exposomics Studies2026
  5. 5From Sampling to Screening: A Review of Targeted and Non-Targeted PFAS Analysis in Environmental Samples2026 · 3 citations