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This research investigates how the loss of glucocorticoid rhythm affects vascular reactivity and gene expression.

November 17, 2025Cardiovascular ResearchOpen Access

“Loss of circulating glucocorticoid rhythm disrupts the circadian transcriptome and vascular reactivity in the mouse renal artery.”

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Corticosterone alters vascular function and transcriptome in mice, indicating relevance to metabolic syndrome and stress.

This research investigates how the loss of glucocorticoid rhythm affects vascular reactivity and gene expression.
Impairment of glucocorticoid rhythm using corticosterone in C57BL6J mice
Measurement of vasoreactivity in renal arteries using wire myography
RNA sequencing conducted on isolated arteries at different times for transcriptome analysis.
Corticosterone treatment flattened glucocorticoid rhythm and altered vascular function
Elevated endothelium-dependent and independent vasodilation observed in healthy mice
156 genes lost rhythmicity, while 492 gained rhythmicity, altering mitochondrial activity.

Krilis et al. (2025) studied this question.

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