Why the study?
Disruption of the endogenous glucocorticoid rhythm causes non-dipping blood pressure, but the underlying mechanisms and vascular contributions remain unclear.
Does impaired glucocorticoid rhythmicity alter time-of-day dependent vascular function and the circadian transcriptome in mouse renal arteries?
Population
Male C57BL6J mice kept on a 12:12 h light/dark cycle
Comparison
Subcutaneous slow-release corticosterone pellet (~3.7 mg/kg/day) vs vehicle pellet
Design
Preclinical animal study
Follow-up
7 days
Authors
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Disrupted glucocorticoid rhythms may impair vascular reactivity; leaves open translation to human metabolic syndrome or chronic stress.
Does impaired glucocorticoid rhythmicity alter time-of-day dependent vascular function and the circadian transcriptome in mouse renal arteries?
Loss of circulating glucocorticoid rhythm disrupts normal circadian variations in vascular reactivity and alters the circadian transcriptome in mouse renal arteries, providing insight into vascular dysfunction in metabolic syndrome and chronic stress.
Krilis et al. (2025) studied this question.
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