What question did this study set out to answer?

The aim is to create a cellular atlas of the human brain after stroke to understand glial responses.

November 16, 2025Experimental NeurologyOpen Access

Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain

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The aim is to create a cellular atlas of the human brain after stroke to understand glial responses.
Single-nuclei RNA sequencing (snRNA-seq) was performed on human cortical samples post-stroke.
An atlas of peri-infarct cell types was generated to characterize cellular responses.
The analysis focused on transcriptional changes in astrocyte and oligodendrocyte lineage cells.
Key genes such as NMNAT2, HIF3A, NRP1, SEZ6L, and GPM6A were found to be upregulated.
Findings highlight the potential of these genes as therapeutic targets for enhancing neuroprotection.
Coordinated glial transcriptional responses observed may contribute to cellular repair processes.

Implication

Single-nuclei RNA sequencing uncovers glial responses in post-stroke brain, suggesting therapeutic targets for neuroprotection.

Abstract

This study provides a peri-infarct human cortical snRNA-seq atlas after IS, revealing coordinated glial transcriptional responses that promote cellular adaptation and repair. The upregulation of NMNAT2, HIF3A, NRP1, SEZ6L, and GPM6A highlights potential therapeutic targets for enhancing neuroprotection and remyelination after stroke.

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Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/692509ffc0ce034ddc353180 https://doi.org/10.1016/j.expneurol.2025.115550

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Implication

Single-nuclei RNA sequencing uncovers glial responses in post-stroke brain, suggesting therapeutic targets for neuroprotection.

Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain

Key Points

Implication

Abstract

Discussion

Cite This Study

Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain

Key Points

Implication

Abstract

Discussion

Cite This Study

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