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November 16, 2025International Journal of Molecular SciencesOpen Access

Late vs. Early Preeclampsia

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Authors

MKMaria KarioriVKVasiliki KatsiCTCostas Tsioufis

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Overview

Review highlights differences in pathophysiology and outcomes between late and early preeclampsia, indicating the need for tailored therapeutic approaches.

Key Points

  • This review aims to differentiate between early-onset and late-onset preeclampsia and their respective implications.
  • Review of current literature on molecular, immunological, and hemodynamic distinctions between EOPE and LOPE.
  • Examination of angiogenic imbalance, oxidative stress, and immune modulation in both preeclampsia types.
  • Evaluation of emerging diagnostic and prognostic biomarkers and potential gene therapies.
  • Identified key differences in maternal and neonatal outcomes related to EOPE and LOPE.
  • Highlighted the role of angiogenic factors such as VEGF and PlGF in preeclampsia pathogenesis.
  • Emphasized the importance of precision-based management strategies for better outcomes.

Cite This Study

Kariori et al. (2025) studied this question.

synapsesocial.com/papers/692509ffc0ce034ddc3532achttps://doi.org/10.3390/ijms262211091
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Also Consider

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  1. 1Clinical Characteristic and Maternal-Perinatal Outcome of Early-Onset vs Late-Onset Preeclampsia: A Systematic Review2026
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  4. 4USING A MULTI-OMICS LANDSCAPE OF THE MATERNAL-FETAL INTERFACE TO MODEL THE LONGITUDINAL PATHOGENESIS OF EARLY-ONSET PRE-ECLAMPSIA2024
  5. 5Understanding Preeclampsia: Cardiovascular Pathophysiology, Histopathological Insights and Molecular Biomarkers2025 · 24 citations