What is the clinical evidence from this study?

Study design: Systematic Review. Population: Preeclampsia. Intervention: Early-Onset Preeclampsia vs. Late-Onset Preeclampsia. Primary outcome: Severity of maternal and perinatal outcomes.

What question did this study set out to answer?

This review evaluates the clinical significance of differences between early-onset and late-onset preeclampsia on maternal and perinatal outcomes.

May 22, 2026Open Access

Clinical Characteristic and Maternal-Perinatal Outcome of Early-Onset vs Late-Onset Preeclampsia: A Systematic Review

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Key result

Early-onset preeclampsia is linked to substantially more lethal maternal and perinatal complications versus late-onset preeclampsia.

Why the study?

This review evaluated the clinical significance of distinct pathophysiological differences between early-onset and late-onset preeclampsia on pregnancy outcomes.

Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in pregnant women?

Population

Patients in 12 primary observational studies

Comparison

Early-onset preeclampsia (<34 weeks) vs late-onset preeclampsia (>=34 weeks)

Design

Systematic review of 12 primary observational studies

Authors

NSNyoman Gede Dikawijaya Satriawan IJI Kadek Ade Juniantara GWGede Resha Wisadianta

Discussion

Member takes

Overview

Supports differentiated surveillance and delivery timing for EO-PE; confirms distinct placental versus cardiometabolic pathways guiding subtype-specific trials.

Key Points

This review evaluates the clinical significance of differences between early-onset and late-onset preeclampsia on maternal and perinatal outcomes.
Systematic review of 12 primary observational studies
Comparison of maternal and perinatal outcomes in early-onset and late-onset preeclampsia
Focus on clinical profiles and complications associated with each type
Early-onset preeclampsia patients had significantly lower gestational ages at delivery and mean birth weights due to more urgent deliveries.
Higher incidence of severe maternal complications like HELLP syndrome and placental abruption in EO-PE group.
Increased perinatal morbidities including extreme prematurity and fetal growth restriction in EO-PE infants, with a high need for NICU admission.

Study Design

Type

Systematic Review

Structured PICO

Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in pregnant women?

Population

Pregnant women with preeclampsia (pooled from 12 primary observational studies)

Intervention

Early-Onset Preeclampsia (EO-PE, <34 weeks)

Comparator

Late-Onset Preeclampsia (LO-PE, ≥34 weeks)

Outcome

Severity of maternal and perinatal outcomeshard clinical

Early-onset preeclampsia presents a substantially more lethal spectrum of maternal and perinatal complications compared to late-onset preeclampsia, underscoring the need for early detection and specific risk stratification.

Cite This Study

Satriawan et al. (2026) conducted a systematic review in Preeclampsia. Early-Onset Preeclampsia vs. Late-Onset Preeclampsia was evaluated on Severity of maternal and perinatal outcomes. Early-onset preeclampsia (<34 weeks) presents a substantially more lethal spectrum of maternal and perinatal complications compared to late-onset preeclampsia (≥34 weeks).

synapsesocial.com/papers/6a0ff3d9d674f7c03778cc02 https://doi.org/10.5281/zenodo.20305715

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May 22, 2026Open Access

Clinical Characteristic and Maternal-Perinatal Outcome of Early-Onset vs Late-Onset Preeclampsia: A Systematic Review

View Full Paper

Ask AI

Bookmark

Key result

Early-onset preeclampsia is linked to substantially more lethal maternal and perinatal complications versus late-onset preeclampsia.

Why the study?

This review evaluated the clinical significance of distinct pathophysiological differences between early-onset and late-onset preeclampsia on pregnancy outcomes.

Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in pregnant women?

Population

Patients in 12 primary observational studies

Comparison

Early-onset preeclampsia (<34 weeks) vs late-onset preeclampsia (>=34 weeks)

Design

Systematic review of 12 primary observational studies

Authors

NSNyoman Gede Dikawijaya Satriawan IJI Kadek Ade Juniantara GWGede Resha Wisadianta

Discussion

Member takes

Overview

Supports differentiated surveillance and delivery timing for EO-PE; confirms distinct placental versus cardiometabolic pathways guiding subtype-specific trials.

Key Points

This review evaluates the clinical significance of differences between early-onset and late-onset preeclampsia on maternal and perinatal outcomes.
Systematic review of 12 primary observational studies
Comparison of maternal and perinatal outcomes in early-onset and late-onset preeclampsia
Focus on clinical profiles and complications associated with each type
Early-onset preeclampsia patients had significantly lower gestational ages at delivery and mean birth weights due to more urgent deliveries.
Higher incidence of severe maternal complications like HELLP syndrome and placental abruption in EO-PE group.
Increased perinatal morbidities including extreme prematurity and fetal growth restriction in EO-PE infants, with a high need for NICU admission.

Study Design

Type

Systematic Review

Structured PICO

Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in pregnant women?

Population

Pregnant women with preeclampsia (pooled from 12 primary observational studies)

Intervention

Early-Onset Preeclampsia (EO-PE, <34 weeks)

Comparator

Late-Onset Preeclampsia (LO-PE, ≥34 weeks)

Outcome

Severity of maternal and perinatal outcomeshard clinical

Cite This Study

synapsesocial.com/papers/6a0ff3d9d674f7c03778cc02 https://doi.org/10.5281/zenodo.20305715

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