Key result
Early-onset preeclampsia was associated with a significantly higher rate of composite adverse neonatal outcomes compared to late-onset preeclampsia (40.4% vs. 12.7%, p<0.001).
Why the study?
The risk factors, clinical trends, and maternal and fetal health of early- and late-onset preeclampsia have not been adequately studied.
Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in women with preeclampsia?
Population
One hundred and fifty women with preeclampsia consecutively enrolled in each group
Comparison
Early-onset preeclampsia (<34 weeks of gestation) vs late-onset preeclampsia (≥34 weeks of gestation)
Design
Consecutive cohort study
Authors
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Early-onset preeclampsia may warrant heightened perinatal surveillance; leaves open whether onset timing refines risk stratification beyond current criteria.
Cohort (n=300)
No
Does early-onset preeclampsia compared to late-onset preeclampsia worsen maternal and perinatal outcomes in women with preeclampsia?
Absolute Event Rate: 40.4% vs 12.7%
p-value: p=<0.001
Early-onset preeclampsia is associated with significantly worse perinatal outcomes compared to late-onset preeclampsia, though maternal outcomes do not differ significantly.
Wadhwani et al. (2020) conducted a cohort in Preeclampsia (n=300). Early-onset preeclampsia vs. Late-onset preeclampsia was evaluated on Composite neonatal outcome (p=<0.001). Early-onset preeclampsia was associated with a significantly higher rate of composite adverse neonatal outcomes compared to late-onset preeclampsia (40.4% vs. 12.7%, p<0.001).
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