Why the study?
Does early-onset and late-onset preeclampsia increase the risk of severe maternal morbidity compared to women without preeclampsia in singleton deliveries?
Population
670,120 singleton deliveries in Washington State between 2000 and 2008
Comparison
Early-onset and late-onset preeclampsia vs Women without preeclampsia
Design
Cohort
Key result
Early-onset preeclampsia was associated with a higher rate of severe maternal morbidity compared to no preeclampsia (12.2 vs 3 per 100 deliveries; aOR 3.7, 95% CI 3.2-4.3).
Authors
Loading...
Supports heightened surveillance for severe maternal morbidity in early-onset preeclampsia; extends prior associations but remains hypothesis-generating in this cohort.
Cohort (n=670,120)
Does early-onset and late-onset preeclampsia increase the risk of severe maternal morbidity compared to women without preeclampsia in singleton deliveries?
Odds Ratio: 3.7 (95% CI 3.2–4.3)
Absolute Event Rate: 12.2% vs 3%
Early-onset preeclampsia is associated with a substantially higher risk of severe maternal morbidity and mortality compared to late-onset preeclampsia and women without the condition.
Lisonkova et al. (2014) conducted a cohort in Preeclampsia (n=670,120). Early-onset preeclampsia vs. Women without preeclampsia was evaluated on Severe maternal morbidity (excluding obstetric trauma) (aOR 3.7, 95% CI 3.2-4.3). Early-onset preeclampsia was associated with a higher rate of severe maternal morbidity compared to no preeclampsia (12.2 vs 3 per 100 deliveries; aOR 3.7, 95% CI 3.2-4.3).