Key result
Late-onset preeclampsia presents with major maternal complications in ~31% of cases.
Why the study?
The clinical profile and outcomes of late-onset preeclampsia were not well described.
Observational (n=264)
Yes
Late-onset preeclampsia is associated with a high rate of severe disease and major maternal complications, demonstrating that it is not a benign condition.
Supports heightened vigilance in late-onset preeclampsia; leaves open optimal risk-stratification and intervention strategies.
OBJECTIVE: To describe the profile and outcome of late-onset preeclampsia (LOPE). METHODS: Retrospective study of 264 singleton pregnancies presenting before delivery at two referral centres in South Africa. RESULTS: Primigravid patients constituted 56.8% of the group, while 57.6% were graded as severe. Median gestational age at diagnosis was 37 (34-43) weeks. 30.7% of patients experienced >or=1 major maternal complication including 34 (12.9%) cases of eclampsia. There were no maternal or early neonatal deaths. Five intrauterine deaths occurred, all due to placental abruption. The perinatal mortality rate was 18.9 per thousand births. CONCLUSIONS: Late-onset preeclampsia often presents as severe disease.
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Kenneth et al. (2010) conducted an observational in Late-onset preeclampsia (n=264). Late-onset preeclampsia was evaluated on Major maternal complication. Late-onset preeclampsia presented as severe disease in 57.6% of cases, with 30.7% experiencing at least one major maternal complication.
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