Fenugreek-Psyllium Biopolymer Hydrogel: Prototyping A Novel pH-Responsive, Antioxidant Wound Dressing for Enhanced Healing

Chronic wounds represent a major healthcare challenge worldwide, emphasizing the need for sustainable and multifunctional wound dressings. Hydrogel-based materials maintain moisture and promote tissue regeneration, yet conventional Psyllium husk (Plantago ovata) hydrogels lack antimicrobial, antioxidant, and diagnostic properties. In this study, a prototype of a Fenugreek Psyllium biopolymer hydrogel was engineered by integrating fenugreek seed gel (Trigonella foenum-graecum) for antimicrobial and anti-inflammatory activity, Indian black carrot extract (Daucus carota subsp. sativus) for anthocyanin-based pH responsiveness, and Aloe vera gel (Aloe barbadensis miller) to enhance hydration and antioxidative capacity. The chromatic response of the hydrogel was evaluated across pH 2-14, fluid retention was measured at 1, 2.5, and 4 hours, and antioxidant activity was quantified using the DCPIP assay. Compared to the Psyllium control, the enhanced hydrogel exhibited distinct pH-dependent color transitions, approximately 33% greater radical-scavenging efficiency, and 60-70% higher fluid absorption. These findings highlight its dual diagnostic and therapeutic functionality, offering a low-cost, biocompatible, and eco-friendly approach for next-generation wound care applications.