What question did this study set out to answer?

The aim is to review recent advances in insulin gene and cell therapies for diabetes management.

November 15, 2025European Journal of Endocrinology

Regulation of insulin expression and release in gene and cell therapy of insulin-deficient diabetes

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The aim is to review recent advances in insulin gene and cell therapies for diabetes management.
Reviewed concepts in regulating insulin expression and release.
Evaluated glucose-responsive insulin gene expression in various cell types.
Assessed rapid-release platforms and engineering strategies for insulin output.
Highlighted the integration of synthetic biology frameworks for improved insulin release.
Identified strategies for glucose-responsive insulin gene expression.
Discussed innovative platforms for insulin secretion that mimic natural pancreatic function.
Emphasized the need for enhanced biosafety and genetic stability in therapies.

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Implication

This review highlights gene and cell therapy advances for regulating insulin release in diabetes, indicating potential for improved glucose homeostasis.

Cite This Study

Xie et al. (2025) studied this question.

synapsesocial.com/papers/69251994c0ce034ddc35383d https://doi.org/10.1093/ejendo/lvaf231

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Implication

This review highlights gene and cell therapy advances for regulating insulin release in diabetes, indicating potential for improved glucose homeostasis.

Regulation of insulin expression and release in gene and cell therapy of insulin-deficient diabetes

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Discussion

Implication

Cite This Study

Regulation of insulin expression and release in gene and cell therapy of insulin-deficient diabetes

Key Points

Discussion

Implication

Cite This Study

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