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November 14, 2025Brain SciencesOpen Access

Multidimensional Phenotyping and Predictive Neuropsychological Modeling of Socio-Cognitive Endophenotypes in Early Parkinson’s Disease

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Authors

EUEsra Demir UnalMÇMelih ÇAMCIGAGülsüm Akdeniz

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Overview

Prospective case-control study reveals that executive functions significantly predict social cognition deficits in Parkinson’s disease, indicating the impact of non-motor symptoms.

Key Points

  • This research examines the socio-cognitive changes in early-stage Parkinson's disease and their relationship with executive functions.
  • Conducted a prospective case-control study with 27 early-stage idiopathic PD patients and 46 healthy controls.
  • Assessed social cognitive abilities using the Edinburgh Social Cognition Test (ESCoT) and executive functions with the Frontal Assessment Battery (FAB).
  • Evaluated group differences and correlations using parametric inferential statistics and modeled predictive contributions with multiple linear regression.
  • PD patients scored significantly lower on the ESCoT compared to healthy controls.
  • Significant predictions of ESCoT total scores from FAB performance were observed, with a strong correlation (r > 0.40).
  • The study highlights that ESCoT can sensitively capture social cognitive deficits in PD, even when global cognitive function is preserved.

Cite This Study

Unal et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc353b9chttps://doi.org/10.3390/brainsci15111223
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