Subjective and objective cognition in early-stage, treatment-naïve Parkinson’s disease: Relationships with mood.

OBJECTIVE: Subjective cognitive complaints (SCCs) are common in Parkinson's disease (PD), yet the relationship among nonmotor symptoms remains understudied in early-stage, treatment-naïve populations. We examined interrelationships among SCCs, mood symptoms, and cognition in early-stage, treatment-naïve PD. We hypothesized that SCCs would relate to executive functioning and processing speed, and these relationships would be moderated by mood. METHOD: tests and Pearson correlations assessed associations among SCC group status, mood symptoms, and cognition. Ordinary least squares regression evaluated whether mood moderated the relationship between SCC group status and cognition. RESULTS: s < .05). No other mood moderation effects were found. CONCLUSIONS: In early-stage, treatment-naïve PD, more SCCs corresponded with worse mood symptoms and worse processing speed and memory. Memory performance was worse when both higher SCCs and elevated state anxiety are present, but mood did not moderate higher SCCs' relationship with other domains. SCCs may be early indication of neurocognitive vulnerability. Longitudinal research is warranted to determine how mood symptoms impact SCCs' utility for predicting cognitive decline. (PsycInfo Database Record (c) 2026 APA, all rights reserved).