This analysis identifies neuropsychiatric predictors and neural correlates of subjective cognitive complaint in elderly populations, indicating potential therapeutic targets.
Key Points
The study aims to explore the relationship between neuropsychiatric symptoms and subjective cognitive complaint in normal elderly and MCI.
Analyzed clinical, cognitive, and imaging data from 233 MCI and 419 normal elderly participants from ADNI-3.
Assessed subjective cognitive complaint using the Cognitive Change Index and Everyday Cognition.
Evaluated neuropsychiatric symptoms through the Neuropsychiatric Inventory.
Measured brain amyloid and tau levels via PET imaging and examined structural MRI data for brain volume.
SCC correlated with depression, anxiety, apathy, irritability, and sleep disorders in MCI.
Depression and anxiety significantly impacted SCC index in MCI individuals.
MCI with SCC exhibited reduced volumes in key brain regions compared to those without SCC.