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July 2, 2026Brain SciencesOpen Access

Combined Influence of Subjective Cognitive Complaints and Neuropsychiatric Symptoms on Cognitive Trajectories in Older Adults

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Authors

CZCindy ZhangAVAshleigh S. VellaRCRussell J. Chander

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Overview

Randomized trial investigates cognitive decline and dementia risk in older adults with complaints and symptoms, suggesting a need for closer monitoring.

Key Points

  • This study aims to explore the combined predictive value of subjective cognitive complaints and neuropsychiatric symptoms for cognitive decline and dementia in older adults.
  • Participants included 468 dementia-free individuals aged 70–90 from a long-term study.
  • Cognitive decline assessed biennially using neuropsychological tests and dementia diagnoses made by expert consensus.
  • Ordinal scores for subjective cognitive complaints and neuropsychiatric symptoms were analyzed with linear regression and Cox proportional hazards models.
  • Participants with greater subjective cognitive complaint scores had an increased dementia risk (HR = 1.66, p = 0.041).
  • Those with neuropsychiatric symptoms alone experienced more cognitive decline in executive function, visuospatial ability, and global cognition.
  • Combination of high subjective complaints and neuropsychiatric symptoms correlated with elevated dementia risk, highlighting a particularly vulnerable subgroup.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a45fffc9ed13430313102fehttps://doi.org/10.3390/brainsci16070693
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Worry Associated with Self-Reported, but Not Informant-Reported, Subjective Cognitive Decline Predicts Increased Risk of Incident Dementia2025
  2. 2Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation2026
  3. 3Neuropsychiatric and neural correlates of subjective cognitive complaint2026
  4. 4Neuropsychiatric Symptoms in Older People with and without Cognitive Impairment2012 · 91 citations
  5. 5Subjective Cognitive Complaints and Somatic Symptoms in Cognitively Healthy Older Adults - Network Analysis Perspective2026