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September 2, 2026Brain and BehaviorOpen Access

Could Subjective Cognitive Complaints Give the Facts of Objective Cognitive Impairments in Non‐Central Nervous System Cancer? A Systematic Review

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Authors

CLChieh‐Ning LiNGNai‐Wen GuoBSBei-Yi Su

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Overview

Systematic review reveals low but significant correlations between subjective complaints and objective tests in non-CNS cancer, suggesting self-reports require demographic and domain adjustments.

Key Points

  • To examine the relationship between subjective cognitive complaints and objective neuropsychological assessments in non-central nervous system cancer patients.
  • Followed PRISMA guidelines to search databases from September 2000 to November 2024 for cross-sectional studies on non-CNS cancer, excluding neurological conditions.
  • Conducted a multilevel meta-analysis in R across 16 eligible studies (N = 2,093) evaluating 156 correlation coefficients to estimate sampling error, within-study variance, and between-study variance.
  • Correlations between subjective cognitive complaints and objective neuropsychological examinations were low but statistically significant.
  • Multilevel modeling showed that 57.18% of variance was within-study variance when evaluating cognitive domains, female ratio, and age disparity.
  • Higher female ratios correlated consistently with attention and memory but inconsistently with executive function, with overall trends shifting when accounting for age disparities.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a98131ec562ede874ec7bfehttps://doi.org/10.1002/brb3.71622
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subjective Cognitive Complaints and Somatic Symptoms in Cognitively Healthy Older Adults - Network Analysis Perspective2026
  2. 2Neuropsychiatric and neural correlates of subjective cognitive complaint2026
  3. 3Subjective cognitive complaints in cognitively unimpaired Parkinson’s disease: Associations with affective burden, motor severity, and awareness-related processes2026
  4. 4Combined Influence of Subjective Cognitive Complaints and Neuropsychiatric Symptoms on Cognitive Trajectories in Older Adults2026
  5. 5The association between subjective and objective cognitive functioning from a transdiagnostic perspective: An umbrella review and meta-analysis2025 · 28 citations