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November 14, 2025International Journal of Molecular SciencesOpen Access

Neurodegeneration Through the Lens of Bioinformatics Approaches: Computational Mechanisms of Protein Misfolding

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Authors

MHMubashir HassanSSSaba ShahzadiAMAhmed A. Moustafa

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Overview

Review uncovers molecular mechanisms of protein misfolding in neurodegenerative diseases, suggesting bioinformatics may aid drug discovery.

Key Points

  • This review aims to explore the bioinformatics approaches related to protein misfolding in neurodegeneration.
  • Review of computational methods for predicting protein aggregation
  • Analysis of bioinformatics tools and databases concerning protein misfolding
  • Evaluation of curated resources for neurodegenerative research
  • Identifies key molecular mechanisms associated with protein aggregation
  • Highlights bioinformatics tools that can aid in drug discovery
  • Suggests therapeutic targets for future research in neurodegenerative diseases

Cite This Study

Hassan et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc353ba2https://doi.org/10.3390/ijms262211021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring Protein Misfolding and Aggregate Pathology in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Interventions2025 · 22 citations
  2. 2Current Understanding of Protein Aggregation in Neurodegenerative Diseases2025 · 14 citations
  3. 3Molecular and Technological Advances in the Treatment of Protein Misfolding Disorders2025
  4. 4Recent Advances in Mapping Protein Self-Assembly and Aggregation for Common Proteinopathies2024 · 1 citations
  5. 5AI-driven insights into protein misfolding and innate immunity in neurodegenerative diseases2026 · 1 citations