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November 14, 2025MedicineOpen Access

Associations between metabolic score for visceral fat and nonalcoholic fatty liver disease (NAFLD) in US adults: A cross-sectional study based on NHANES 2017–2020

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Authors

JLJuan LiSDShenglan Dai

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Overview

Cross-sectional study reports significant association between metabolic score for visceral fat and NAFLD prevalence, indicating obesity as a risk factor.

Key Points

  • To explore the relationship between the metabolic score for visceral fat and nonalcoholic fatty liver disease in US adults.
  • Analyzed data from 3025 participants in the National Health and Nutrition Examination Survey 2017-2020
  • Utilized weighted multivariable-adjusted logistic regression to evaluate associations
  • Employed generalized additive model for potential nonlinear associations
  • Conducted subgroup analysis to identify susceptible populations
  • Prevalence of NAFLD increased with higher METS-VF quartiles (P < .001)
  • Odds ratio for NAFLD in highest METS-VF quartile was 6.28 (95% CI: 2.94-13.38)
  • Identified an S-shaped association with an inflection point at 5.17
  • Positive correlation observed across all subgroups analyzed

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc35420ahttps://doi.org/10.1097/md.0000000000045082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Between Metabolic Score for Visceral Fat and Liver Fibrosis Risk in Non-Viral Hepatitis Populations: NHANES 2017–20202025
  2. 2The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes2023 · 34 citations
  3. 3Association between visceral fat metabolism score and atherosclerotic cardiovascular disease: evidence from NHANES 2005 to 20162025 · 3 citations
  4. 4METS-VF as a novel predictor of gallstones in U.S. adults: a cross-sectional analysis (NHANES 2017–2020)2025 · 4 citations
  5. 5Association between metabolic score of visceral fat and all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a follow-up study based on NHANES III (1988–1994)2025 · 1 citations