Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 14, 2025Neurological Research and PracticeOpen Access

The clinical relevance of hyper-reflective foci in the inner retina at the diagnosis of multiple sclerosis

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMarco PuthenparampilAMAlessandro MisciosciaEBElisa Basili

Discussion

Loading...

Member takes

Overview

Retrospective cohort study shows higher HRF in Inner Nuclear Layer indicates increased therapeutic switch risk in multiple sclerosis.

Key Points

  • Evaluate the risk of therapeutic failure related to hyper-reflective foci in multiple sclerosis patients.
  • Retrospective cohort study of 57 treatment-naive patients with multiple sclerosis.
  • Patients categorized by treatment type: platform-therapy and high efficacy therapy.
  • Follow-up to assess time to therapeutic switch based on HRF count in Inner Nuclear Layer.
  • Increased HRF-INL count correlates with higher risk of therapeutic switch (HR 7.9, p < 0.0001).
  • Switching patients had significantly higher HRF counts compared to non-switching patients (45.80 vs 31.75, p < 0.05).

Cite This Study

Puthenparampil et al. (2025) studied this question.

synapsesocial.com/papers/692519b4c0ce034ddc354437https://doi.org/10.1186/s42466-025-00447-3
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperreflective focuses as a biomarker of multiple sclerosis progression2024
  2. 2Hyper-reflective foci changes in RRMS under natalizumab therapy2024 · 5 citations
  3. 3Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis2026
  4. 4Longitudinal Optical Coherence Tomography Imaging Reveals Hyperreflective Foci Characteristics in Relapsing–Remitting Multiple Sclerosis Patients2024
  5. 5Prevalence and associations of intraretinal hyperreflective foci in age-related macular degeneration: the Beijing Eye Study2026