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November 13, 2025BiomedicinesOpen Access

The Kidney in the Shadow of Cirrhosis: A Critical Review of Renal Failure

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Authors

LPLivia Mirela PopaPAPaula AndercoOSOana Stoia

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Overview

Critical review highlights hepatorenal syndrome and acute kidney injury in liver disease, suggesting urgent diagnostic and treatment strategies.

Key Points

  • To review renal failure in the context of cirrhosis, focusing on hepatorenal syndrome and its mechanisms.
  • Review of pathophysiology, diagnosis, and management related to renal failure in cirrhosis.
  • Comparison of hepatorenal syndrome with acute tubular necrosis.
  • Discussion of treatment strategies including removal of nephrotoxins and initiation of vasoconstrictors.
  • Hepatorenal syndrome presents high mortality but may be reversible with early intervention.
  • Novel diagnostic strategies prioritize creatinine kinetics and recognize non-acute kidney injury phenotypes.
  • Effective management includes structured volume assessment and strategic use of albumin and vasoconstrictors.

Cite This Study

Popa et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc354779https://doi.org/10.3390/biomedicines13112775
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in the management of Hepatorenal syndrome2026
  2. 2Hepatorenal Syndrome in Focus: Emerging Diagnostic Criteria and Current Therapeutic Approaches.2026
  3. 3Hepato–Cardio–Renal Interactions and Transplant Implications2026
  4. 4Seeing and Sensing the Hepatorenal Syndrome (HRS): The Growing Role of Ultrasound-Based Techniques as Non-Invasive Tools for the Diagnosis of HRS2024 · 2 citations
  5. 5An Integrated Review of Hepatorenal Syndrome2024 · 1 citations