November 13, 2025Journal of the American Chemical Society

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

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Authors

PBPatricia BrandlÉcole Polytechnique Fédérale de Lausanne LLLukas Lüthy FPFelix Pultar

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Molecular dynamics explores bioactivity and structure-activity relationships of lipopeptide mutanobactin D in Candida albicans, highlighting its human microbiome role.

Key Points

Bioactivity is influenced by C26 configuration in mutanobactin D analogs, which inhibit Candida albicans morphogenesis.
The study employs molecular dynamics simulations to examine conformations of mutanobactin D and its analogs across different environments.
Stereoselective synthesis reveals critical structural attributes underpinning the lipopeptide's function, including membrane interaction effects.
Research advances understanding of natural products' roles in the human microbiome, supporting further exploration of bioactive compounds.

Cite This Study

Brandl et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3547f6 https://doi.org/10.1021/jacs.5c08850

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Implication

Molecular dynamics explores bioactivity and structure-activity relationships of lipopeptide mutanobactin D in Candida albicans, highlighting its human microbiome role.

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

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Member takes

Implication

Key Points

Cite This Study

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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