What question did this study set out to answer?

To establish the structure–activity relationships and conformational mechanism by which the human microbiome-derived lipopeptide mutanobactin D inhibits Candida albicans morphogenesis.

November 13, 2025Journal of the American Chemical Society

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

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Authors

PBPatricia BrandlETH Zurich LLLukas LüthyETH Zurich FPFelix PultarETH Zurich

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Implication

Biochemical and molecular dynamics study reveals structural determinants of mutanobactin D activity in Candida albicans, indicating membrane-dependent conformational mechanisms.

Key Points

To establish the structure–activity relationships and conformational mechanism by which the human microbiome-derived lipopeptide mutanobactin D inhibits Candida albicans morphogenesis.
Synthesized designed mutanobactin D analogs stereoselectively to test the biological impact of specific chiral configurations on yeast-to-hyphae morphogenesis in C. albicans.
Conducted molecular dynamics simulations of mutanobactin D and analogs across monophasic (water, chloroform), interfacial (water/chloroform), and explicit phosphatidylcholine lipid membrane environments.
Stereoselective evaluation demonstrated that the C26 configuration within the C26–C28 lipid motif is strictly required to inhibit pathogenic yeast-to-hyphae transition in C. albicans without displaying fungicidal or fungistatic activity.
Interfacial and explicit lipid membrane simulations revealed that only bioactive analogs adopt a dominant, stable conformation that organizes a continuous, structured water cushion at the membrane interface.

Cite This Study

Brandl et al. (2025) studied this question.

synapsesocial.com/papers/6a8655650e354d9fd799a2a9 https://doi.org/10.1021/jacs.5c08850

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Implication

Biochemical and molecular dynamics study reveals structural determinants of mutanobactin D activity in Candida albicans, indicating membrane-dependent conformational mechanisms.

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

Mutanobactin D from the Human Microbiome: Chemistry, Biology, and Molecular Dynamics Studies

Discussion

Member takes

Implication

Key Points

Cite This Study

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