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November 13, 2025The Journal of Physiology

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

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Authors

GBGeoanna M. BautistaLSL. Fernando SantanaMMMartin G Martin

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Overview

Conceptual review highlights Piezo1's impact on gut motility and smooth muscle mechanotransduction mechanisms.

Key Points

  • To explore the role of Piezo1 in intestinal smooth muscle cells and its effects on gut motility.
  • Conceptual review focusing on the mechanotransduction machinery of smooth muscle cells.
  • Analysis of Piezo1's localization and interaction with intracellular channels like ryanodine and IP3 receptors.
  • Discussion of Piezo1's role in translating mechanical forces into Ca2+ signals.
  • Piezo1 is crucial in regulating intestinal motility through mechanotransduction.
  • Deletion of Piezo1 impairs small bowel contractility and tissue mechanics.
  • Piezo1 has a unique localization within smooth muscle cells, indicating a distinct mechanotransduction role.

Cite This Study

Bautista et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3547f9https://doi.org/10.1113/jp287636
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracellular Piezo1 Modulates Intestinal Smooth Muscle Excitability2026
  2. 2The Role of Piezo-Type Mechanosensitive Ion Channel Component 1 in Inflammatory Bowel Disease2025 · 4 citations
  3. 3Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies2025 · 31 citations
  4. 4Piezo1 in immune cells: from mechanosensation to immunoregulation2026
  5. 5Piezo1 mediated calcium-calcineurin signaling pathway regulates gastrointestinal smooth muscle cell phenotype in a stiffness dependent manner2024 · 2 citations