Busulfan and melphalan (Bu-Mel) versus carboplatin, etoposide, and melphalan (CEM) conditioning regimens for autologous haematopoietic stem cell transplant in children and young adults with high-risk neuroblastoma

Aditya Kumar Gupta; Jagdish Prasad Meena; Shivam Bansal; Sanjana Sarangarajan; Manisha Komal; M. Jeeva Sankar

doi:10.1002/14651858.cd015131

November 13, 2025Cochrane libraryOpen Access

Busulfan and melphalan (Bu-Mel) versus carboplatin, etoposide, and melphalan (CEM) conditioning regimens for autologous haematopoietic stem cell transplant in children and young adults with high-risk neuroblastoma

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Key Points

To evaluate the effectiveness and safety of two conditioning regimens for stem cell transplant in young patients with neuroblastoma.
Cochrane Review protocol comparing two regimens: Bu-Mel and CEM.
Target population: children and young adults aged 0 to 21 years with high-risk neuroblastoma.
Focus on the efficacy and safety of the conditioning chemotherapy methods.
Bu-Mel versus CEM outcomes are analyzed for safety and effectiveness in treating high-risk neuroblastoma.

Implication

Cochrane review shows Bu-Mel may improve outcomes in children with high-risk neuroblastoma compared to CEM.

Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To compare the efficacy and safety of busulfan and melphalan (Bu-Mel) conditioning chemotherapy with carboplatin, etoposide, and melphalan (CEM) conditioning chemotherapy for autologous haematopoietic stem cell transplantation in children and young adults (0 to 21 years of age) with high-risk neuroblastoma.

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Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc354894 https://doi.org/10.1002/14651858.cd015131

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Busulfan and melphalan (Bu-Mel) versus carboplatin, etoposide, and melphalan (CEM) conditioning regimens for autologous haematopoietic stem cell transplant in children and young adults with high-risk neuroblastoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Busulfan and melphalan (Bu-Mel) versus carboplatin, etoposide, and melphalan (CEM) conditioning regimens for autologous haematopoietic stem cell transplant in children and young adults with high-risk neuroblastoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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