Phase 2 study found melphalan, gemcitabine, and carboplatin can treat relapsed germ cell tumors effectively.
Sequential carboplatin/etoposide based high-dose chemotherapy with stem cell support is a standard therapy option for relapsed germ-cell tumors resulting in cure for approximately 50% of patients. In a recent single-center phase 2 study, results were reported for a novel combination including gemcitabine, melphalan, docetaxel and carboplatin.
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Kollmannsberger et al. (2025) studied this question.
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