What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

This meta-analysis assesses the effectiveness of saline and N-acetylcysteine in preventing contrast-associated acute kidney injury (CA-AKI).

November 12, 2025Frontiers in MedicineOpen Access

Saline and N-acetylcysteine-based strategies and other approaches to prevent the risk of CA-AKI: a meta-analysis

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Authors

ILI.-Chen Lin WTWen-Wen Tsai VWVin-Cent Wu

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Implication

Meta-analysis shows hydration and N-acetylcysteine reduce incidence of CA-AKI in cardiovascular angiography, indicating effective prevention strategies.

Key Points

This meta-analysis assesses the effectiveness of saline and N-acetylcysteine in preventing contrast-associated acute kidney injury (CA-AKI).
Systematic search for randomized controlled trials from PubMed, Embase, and Cochrane library.
Participants included adults undergoing cardiovascular angiography assessed for CA-AKI risk.
Comparison of saline plus N-acetylcysteine strategies with hydration alone using network diagrams and statistical ranking.
Included 72 trials with 14,671 patients and 1,843 AKI events.
Incidence of CA-AKI was 11.74% in hydration with oral NAC versus 15.49% in saline alone (OR 0.78).
Hydration with intravenous NAC resulted in 10.62% CA-AKI incidence (OR 0.71).
Hydration with oral NAC and statin group had 8.28% CA-AKI incidence (OR 0.47).

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/692523cec0ce034ddc35528c https://doi.org/10.3389/fmed.2025.1608626

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Implication

Meta-analysis shows hydration and N-acetylcysteine reduce incidence of CA-AKI in cardiovascular angiography, indicating effective prevention strategies.

Saline and N-acetylcysteine-based strategies and other approaches to prevent the risk of CA-AKI: a meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Saline and N-acetylcysteine-based strategies and other approaches to prevent the risk of CA-AKI: a meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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