What question did this study set out to answer?

The aim is to evaluate the effectiveness of sodium bicarbonate and N-acetylcysteine compared to hydration alone in preventing contrast-associated acute kidney injury.

July 11, 2026PLoS ONEOpen Access

Sodium Bicarbonate versus N-Acetylcysteine plus hydration versus hydration alone for preventing contrast-associated acute kidney injury: A single-center retrospective analysis with propensity score matching

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Authors

YMYing-Huan MaNorthern Hospital WWWei WeiNorthern Hospital NLNan K. LiAnhui Agricultural University

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Implication

Retrospective analysis compares hydration, hydration plus N-acetylcysteine, and hydration plus sodium bicarbonate for preventing kidney injury.

Key Points

The aim is to evaluate the effectiveness of sodium bicarbonate and N-acetylcysteine compared to hydration alone in preventing contrast-associated acute kidney injury.
Single-center retrospective observational study conducted from June 2022 to January 2025.
240 adult patients undergoing contrast-enhanced CT or angiography, allocated 1:1:1 into three groups.
Propensity score matching performed to minimize confounding bias.
CA-AKI incidence was 15.00% in the control group, 2.50% in the NAC group, and 7.50% in the sodium bicarbonate group.
NAC significantly reduced CA-AKI risk compared to hydration alone (RR = 0.17, 95% CI: 0.04–0.74, Bonferroni-adjusted P = 0.004).
No significant difference in renal replacement therapy requirement or hospital stay duration across groups.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6a51df22c18d7f28ca500754 https://doi.org/10.1371/journal.pone.0353461

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Implication

Retrospective analysis compares hydration, hydration plus N-acetylcysteine, and hydration plus sodium bicarbonate for preventing kidney injury.

Sodium Bicarbonate versus N-Acetylcysteine plus hydration versus hydration alone for preventing contrast-associated acute kidney injury: A single-center retrospective analysis with propensity score matching

Discussion

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Implication

Key Points

Cite This Study

Sodium Bicarbonate versus N-Acetylcysteine plus hydration versus hydration alone for preventing contrast-associated acute kidney injury: A single-center retrospective analysis with propensity score matching

Discussion

Member takes

Implication

Key Points

Cite This Study

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