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November 12, 2025International Journal of Molecular SciencesOpen Access

Juvenile and Osteoarthritic Human Chondrocytes Under Cyclic Tensile Strain: Transcriptional, Metabolic and Kinase Responses

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Authors

BLBirgit LohbergerVGVincent GroteHKHeike Kaltenegger

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Overview

This study compares chondrocyte responses in osteoarthritis and juvenile cells under strain, revealing distinct mechanotransduction pathways.

Key Points

  • To compare gene expression, metabolism, and signaling responses in juvenile and osteoarthritic chondrocytes under mechanical stimulation.
  • Juvenile and osteoarthritic chondrocytes were mechanically stimulated using the Flexcell™ FX5K system.
  • Gene expression and protein phosphorylation were analyzed pre- and post-stimulation.
  • Principal component analysis identified differences in molecular and signaling profiles.
  • Distinct biomarker and expression patterns were observed between juvenile and osteoarthritic chondrocytes.
  • Significant differences in gene expression included upregulation of COL1 and RUNX2 in juvenile chondrocytes.
  • Cyclic tensile strain influenced MMP1 and other markers, indicating varied mechanotransduction in cell types.

Cite This Study

Lohberger et al. (2025) studied this question.

synapsesocial.com/papers/692523d4c0ce034ddc355422https://doi.org/10.3390/ijms262210934
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions2026 · 1 citations
  2. 2Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids2024 · 2 citations
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  5. 5Osteoarthritis and Chondrocytes: On the Road from Mechanisms to Treatment2025 · 4 citations