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June 14, 2026PLoS ONEOpen Access

Molecular characterization of superficial zone chondrocytes under pro-inflammatory and biomechanical stress conditions

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Authors

FLFang LiuXDXueting DingPLPengcui Li

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Overview

Randomized trial examines inflammatory effects on superficial zone chondrocytes, suggesting targets for intervention.

Key Points

  • This research aims to characterize superficial zone chondrocytes under inflammatory and mechanical stress.
  • Isolated superficial zone chondrocytes in vitro and assessed their properties under simulated inflammatory conditions.
  • Examined the impact of cyclic mechanical stretching on chondrocytes in inflammatory settings.
  • Inflammatory conditions reduced expression of stemness-associated markers in superficial zone chondrocytes.
  • Cyclic mechanical stretching increased Piezo1 expression and enhanced mechanotransduction sensitivity.
  • Aggravated catabolic responses and apoptosis were observed under inflammatory mechanical stimulation.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4704b1cc60ccdea8ba5ehttps://doi.org/10.1371/journal.pone.0350746
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